Antibacterial Properties of Some Macromycetes




Antibacterial activity, Macromycetes, Biologically active substances


Background. The constant emergence of pathogen forms and their new species multi-resistant to existing drugs, and the frequent occurrence of side effects of these drugs cause need to find new antibiotic compounds, especially anti­biotics of natural origin (from plants, fungi, mosses). Fungi are promising object of research because of pro­duction of various biologically active substances.

Objective. The aim of the paper is to analyze the results of research of antibacterial properties of various macromycetes representatives and determine prospects of their practical application.

Methods. The analysis and generalisation of information about objects and methods of macromycetes antibacterial activity research.

Results. Much attention is paid to Basidiomycetes among macromycetes, especially species of the genus Agaricus, Ganoderma, Lentinus, Phellinus, Pleurotus, Polyporus, Trametes. In practice macromycetes are used both as fruiting bodies, biomass and culture liquid and as isolated antibiotic substances. Therefore, edible species of fungi are preferred (Agaricus sp., Pleurotus sp. and Lentinus sp.).

Conclusions. Considering the diversification of investigations dedicated to the search for antibacterial properties of fungi, obtained data on antibiotic activity are quite hard to generalize. Studying of antibacterial activity, action mechanisms is especially important and promising research direction of antibacterial compounds found in macromycetes for further implementation of antibiotics and/or components based on culture liquid, mycelium and fruiting bodies of fungi.

Author Biographies

Tetiana Zaichenko, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”

Student, Department of the Industrial Biotechnology, Faculty of Biotechnology and Biotechnics

Tetiana Krupodorova, Institute of Food Biotechnology and Genomics, NAS of Ukraine

Ph.D (biological sciences), research fellow, Department of Industrial and Food Biotechnology, Laboratory of the Processes of Vegetable Raw Materials Extraction and Bioconversion

Victor Barshteyn, Institute of Food Biotechnology and Genomics, NAS of Ukraine

Ph.D. (technical sciences), research fellow, Department of Industrial and Food Biotechnology, Director of the Laboratory of the Processes of Vegetable Raw Materials Extraction and Bioconversion

Nataliіa Dekhtiarenko, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”

Ph.D (agricultural sciences), Faculty of Biotechnology and Biotechnics, assistance professor at the Industrial Biotechnology Department


L. Yui et al., Medicinal Fungi in Traditional Chinese Medicine and Modern Biotechnology. Kirov, Russia: O-Kratkoye, 2009 (in Russian).

K.R. Ranadive et al., “Glimpses of antimicrobial activity of fungi from world”, J. New Biol. Rep., vol. 2, no. 12, pp. 142–162, 2013.

M.J. Alves et al., “A review on antimicrobial activity of mushroom (Basidiomycetes) extracts and isolated compounds”, Plan­ta Medica, vol. 78, no. 16, pp. 1707–1718, 2012. doi: 10.1055/s-0032-1315370

Biological Features of Medicinal Macromycetes in Culture, vol. 1, S. Vasser, Ed. Kyiv, Ukraine: Alterpres, 2011 (in Russian).

T.A. Krupodorova et al., “Antibacterial activity of macromycetes mycelia and culture liquid”, Microbiol. Biotechnol. Lett., vol. 44, no. 3, pp. 246–253, 2016. doi: 0.4014/mbl.1603.03003

L. Dzyhun et al., “Antimicrobial properties of xylotroph basidiomycetes Laetiporus sulphureus (Bull.: Fr.) murrill”, Visnyk Na­tsi­onalnogo Universitetu “Lvivska Polytekhnika”, no. 700, pp. 156–160, 2011 (in Ukrainian).

T.A. Krupodyorova et al., “Antimicrobial activity of Ganoderma applanatum (Pers.: Wallr.) Pat. and G. lucidum (Curt.: Fr.) P. Karst. strains in the submerged conditions”, Ukr. Botan. J., vol. 65, no. 4, pp. 590–595, 2008 (in Ukrainian).

A. Imtiaj and T.S. Lee, “Screening of antibacterial and antifungal activities from Korean wild mushrooms”, World J. Agric. Sci., vol. 3, no. 3, pp. 316–321, 2007.

S. Dighe and A.D. Agate, “Antibacterial activity of some Indian mushroоms”, Int. J. Med. Mushrooms., no. 2, pp. 141–150, 2000.

M. Yamac and F. Bilgili, “Antimicrobial activities of fruit bodies and/or mycelial cultures of some mushroom isolates”, Phar­ma­ceutical Biology, vol. 44, no. 9, pp. 660–667, 2006. doi: 10.1080/13880200601006897

B.L. Chelela and M.M.A. Chacha, “Antibacterial and antifungal activities of selected wild mushrooms from Southern High­lands of Tanzania”, Amer. J. Res. Comm., vol. 2, no. 9, pp. 58–68, 2014.

E.H.O. Moglad and A.M. Saadabi, “Screening of antimicrobial activity of wild mushrooms from Khartoum state of Sudan”, Micrlobiol. J., vol. 2, no. 2, pp. 64–69, 2012. doi:10.3923/mj.2012.64.69

M. Akyuz et al., “Antimicrobial activity of some edible mushrooms in the Eastern and Southeast Anatolia Region of Turkey”, Gazi Univ. J. Sci., vol. 23, no. 2, pp. 125–130, 2010.

L.H. Rosa et al., “Screening of Brazilian basidiomycetes for antimicrobial activity”, Mem. Inst. Oswaldo Cruz., vol. 98, no. 7, pp. 967–974, 2003.

I. Tsvetkova et al., “Antibacterial activity of some Bulgarian higher basidiomycetes mushrooms”, Int. J. Med. Mushr., vol. 8, no. 1, pp. 63–66, 2006. doi: 10.1615/IntJMedMushr.v8.i1.80

I.I. Sidorova and L.L. Velikanov, “Bioactive substances of agaricoid basidiomycetes and their possible role in regulation of myco- and microbiota structure in soils of forest ecosystems. I. Antibiotic activity of water extracts from basidioms of several dominant agaricoid basidiomycetes”, Mikol. Fitopatol., no. 34, pp. 11–17, 2000.

N. Bala et al., “Evaluation of antibacterial activity of Australian basidiomycetous macrofungi using high-throughput 96-well plate assay”, Pharm. Biol., vol. 49, no. 5, pp. 492–500, 2011. doi: 10.3109/13880209.2010.526616

S.E. Abah and G. Abah, “Antimicrobial and antioxidant potentials of Agaricus bisporus”, Adv. Biological Res., vol. 4, no. 5, pp. 277–282, 2010.

M. Manimozhi and V. Kaviyarasan, “Nutritional composition and antibacterial activity of indigenous edible mushroom Agaricus heterocystis”, Int. J. Adv. Biotechnol. Res., vol. 4, no. 1, pp. 78–84, 2013.

R. Novak and D.M. Shlaes, “The pleuromutilin antibiotics: a new class for human use”, Curr. Opin. Investig. Drugs, vol. 11, no. 2, pp. 182–191, 2010.

P.H.K. Ngai and T.B. Ng, “A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-caju”, Peptides, vol. 25, no. 1, pp. 11–17, 2004. doi: 10.1016/j.peptides.2003.11.012

D. Schillaci et al., “Antibacterial activity of mediterranean oyster mushrooms, species of genus Pleurotus (higher basidiomyce­tes)”, Int. J. Med. Mushrooms, vol. 15, no. 6, pp, 591–594, 2013. doi: 10.1615/IntJMedMushr.v15.i6.70

E.A. Adebayo et al., “Antimicrobial and anti-inflammatory potential of polysaccharide from Pleurotus pulmonarius LAU 09”, Afr. J. Microbiol. Res., vol. 6, no. 13, pp. 3315–3323, 2012. doi: 10.5897/AJMR12.213

M.P. de Carvalho et al., “Investigation of the antibacterial activity of basidiomycetes Lentinula boryana and Lentinula edo­des”, Biocencias, vol. 15, no. 2, pp. 173–179, 2007.

R.A.A. Mothana et al., “Ganomycins A and B, new antimicrobial farnesyl hydroquinones from the basidiomycete Ganoderma pfeifferi”, J. Nat. Prod., vol. 63, no. 3, pp. 416–418, 2000. doi: 10.1021/np990381y

A. Ameri et al., “In vitro evaluation of anti-staphylococcal activity of Ganoderma lucidum, Ganoderma praelongum and Ganoderma resinaceum from Pune, India”, Afr. J. Microbiol. Res., vol. 5, no. 3, pp. 328–333, 2011.

M. Sidorenko et al., “Strain of basidial fungus Fomitopsis officinalis showing antibacterial activity against bacteria Yersinia pseudotuberculosis”, Russia Patent 2375439, Dec. 10, 2009 (in Russian).

A. Sharikov, “The study of the anti-bacterial activity of metabolites of some higher fungi of Middle Siberia”, Sovremennie Nau­koyomkie Tekhnologii, no. 6, pp. 128–129, 2010 (in Russian).

A. Sharikov, “Chaga Mushroom Inonotus obliquus Pilat: antibiotic activity of metabolites”, Sovremennie Naukoyomkie Tekh­no­logii, no. 8, pp. 167–168, 2010 (in Russian).

M. Zerova et al., Mushrooms: Edible, Conditionally Edible, Non-Edible, Poisonous. Kyiv, SU: Urozhay, 1979 (in Ukrainian).

Z. Alresly et al., “Bioactive triterpenes from the fungus Piptoporus betulinus”, Rec. Nat. Prod., vol. 10, no. 1, pp. 103–108, 2016.

T.A. Krupodyorova et al., “Growth and antibacterial activity of Piptoporus betulinus (Bull.) P. Karst. in culture”, in Proc. Int. Conf. Drugs for Humans. Modern Problems of Pharmacotherapy and Prescribing of Drugs, Kharkiv, Ukraine, March 30–31, 2017, vol. 2, pр. 188–189 (in Ukrainian).

H. Zheng et al., “Purification and characterization of an antibacterial protein from the cultured mycelia of Cordyceps sinensis”, Wuhan Univ. J. Nat. Sci., vol. 11, pp. 709–714, 2006. doi: 10.1007/BF02836695

I. Кlechak and L. Antonenko, “Biotechnology on the basis of the higner basidiomycetous mushrooms of genus Coriolus Quel”, Naukovi Visti NTUU KPI, no. 3, pp. 41–49, 2012 (in Ukrainian).