Quantitative Evaluation of the Absolute Value of the Cerebral Blood Flow According to the Scintigraphic Studies with 99MTC-HMPAO

Nykolai Nikolov, Serhei Makeyev, Olha Yaroshenko, Tatiana Novikova, Marina Globa


Background. Represented by physical and mathematical model of cerebral hemodynamics, considered as a flow system.

Objective. Development of cerebral blood flow quantification procedure according to scintigraphy data with 99mTc-HMPAO.

Methods. Analytical, numerical and experimental study of the kinetics 99mTc-HMPAO in brain.

Results. For the purpose of quantitative assessment of volumetric cerebral blood flow according to the data of scintigraphy with 99mTc-HMPAO, it was suggested to view the brain as a flow system. This allows calculating volumetric cerebral blood flow after numerical determination of the model parameters according to the results of indirect angiography and establishment of effective blood dilution volume in brain using single-photon emission-computed tomography. In this case, the suggested blood flow calculation procedure does not require any a priori knowledge of hemodynamics in a certain reference area.

Conclusions. Preliminary clinical studies allow characterizing the suggested approach to calculation of volumetric cerebral blood flow absolute values as appropriate.


Brain; Perfusion; Cerebral blood flow; Mathematical modeling; 99mTc-HMPAO; SPECT

Full Text:



Diagnostics and Treatment of Chronic Forms of Cerebral Circulatory Insufficiency in Patients with Essential Hypertension, V.F. Mordovin and R.S. Karpov, eds. Tomsk, Russia: SST, 2011 (in Russian).

L.A. Bockeria et al., “Diagnostic methods of cerebral hemodynamics and the level of cerebral perfusion in patients with occluding lesions of brachiocephalic arteries”, The Bulletin of A.N. Bakoulev Scientific Center for Cardiovascular Surgery of Russian Academy of Medical Sciences. Cardiovascular Diseases, vol. 13, no. 1, pp. 5–17, 2012 (in Russian).

K. Borch and G. Greisen, “99mTc-HMPAO as a tracer of cerebral blood flow in newborn infants”, J. Cereb. Blood Flow Metab., 1997, no. 17, pp. 448–454. doi: 10.1097/00004647-199704000-00010

N.A. Lassen et al., “The retention of [99mTc]-d,I-HM-PAO in the human brain after intracarotid bolus injection: A kinetic analysis”, J. Cereb. Blood Flow Metab., no. 8, pp. S13–S22, 1988. doi: 10.1038/jcbfm.1988.28

A.R. Andersen et al., “Quantitative measurements of cerebral blood flow using SPECT and [99mTc]-d,I-HM-PAO compared to Xenon-I33”, J. Cereb. Blood Flow Metab., no. 8, pp. S69–S81, 1988. doi: 10.1038/jcbfm.1988.35

H. Fro et al., “Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry”, Annals Nucl. Med., vol. 20, no. 2, pp. 131–138, 2006. doi: 10.1007/BF02985625

M. Kameyama, “Lassen’s equation is a good approximation of permeability-surface model: new a values for 99mTc-HMPAO and 99mTc-ECD”, J. Cereb. Blood Flow Metab., vol. 34, pp. 1157–1161, 2014. doi: 10.1038/jcbfm.2014.64

K. Murase et al., “Kinetic behavior of Technetium-99m-HMPAO in the human brain and quantification of cerebral blood flow using dynamic SPECT”, J. Nucl. Med., vol. 33, no. 1, pp. 135–143, 1992.

I.A. Illán et al., “Bilateral symmetry aspects in computer-aided Alzheimer’s disease diagnosis by single-photon emission-computed tomography imaging”, Artif. Intell. Med., no. 56, pp. 191–198, 2012. doi: 10.1016/j.artmed.2012.09.005

N.A. Nikolov et al., “Integral estimate of spatial distribution of 99mTc-HMPAO in brain of patients with mild cognitive changes”, Radioelectron. Commun. Syst., vol. 57, no. 12 (630), pp. 52–61, 2014. doi: 10.3103/S073527271412005X

GOST Style Citations

DOI: http://dx.doi.org/10.20535/1810-0546.2017.1.91646


  • There are currently no refbacks.