Quantitative Evaluation of the Absolute Value of the Cerebral Blood Flow According to the Scintigraphic Studies with 99MTC-HMPAO

Nykolai Nikolov, Serhei Makeyev, Olha Yaroshenko, Tatiana Novikova, Marina Globa


Background. Represented by physical and mathematical model of cerebral hemodynamics, considered as a flow system.

Objective. Development of cerebral blood flow quantification procedure according to scintigraphy data with 99mTc-HMPAO.

Methods. Analytical, numerical and experimental study of the kinetics 99mTc-HMPAO in brain.

Results. For the purpose of quantitative assessment of volumetric cerebral blood flow according to the data of scintigraphy with 99mTc-HMPAO, it was suggested to view the brain as a flow system. This allows calculating volumetric cerebral blood flow after numerical determination of the model parameters according to the results of indirect angiography and establishment of effective blood dilution volume in brain using single-photon emission-computed tomography. In this case, the suggested blood flow calculation procedure does not require any a priori knowledge of hemodynamics in a certain reference area.

Conclusions. Preliminary clinical studies allow characterizing the suggested approach to calculation of volumetric cerebral blood flow absolute values as appropriate.


Brain; Perfusion; Cerebral blood flow; Mathematical modeling; 99mTc-HMPAO; SPECT

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