Development of the Antiseptic Means Compositions on the Basis Of Cytorecifen
DOI:
https://doi.org/10.20535/1810-0546.2015.3.61599Keywords:
Antiseptics, Prepared forms, Cytorecifen, Auxiliary mattersAbstract
Background. The practical use of bioactive substances becomes complicated by their instability, complication of pre-treatment and causing. The use of auxiliary matters is given by possibility to create the comfortable for application prepared form of preparation and correct activity of substance.
Оbjective. The wide spectrum of antimicrobial action of enzyme preparation of Cytorecifen provides grounds to examine him as perspective basis for the soft prepared forms of preparation. Therefore, the purpose of work is to develop composition of the soft prepared form of preparation-antiseptic for medicine and veterinary on the basis of Cytorecifen.
Methods. The lytic activity of enzyme complex and it the prepared forms determined a turbidimetric method by the capacity of degradation of suspension of microbe test-culture.
Results. It was determined the influence of basic shape-generating auxiliary materials (proksanol-268, PEO-400, PEG-600, PEG-1000, and glycerin), preservatives and anesthetic (miramistin, ofloksacyn, dimeksid, lidocaine) on lytic activity of bacteriolytic enzyme preparation of Cytorecifen. It was proved an absence of substantial negative influence of the chosen auxiliary materials on activity of enzyme, and consequently possibility of their use in composition the prepared forms of preparation.
Conclusions. The composition of antiseptic ointment is offered for veterinary and medical application on the basis of polyoxyethylen, proksanola 268, glycerin, lidocaine and ofloksacyn, containing 40 mg/ml of enzyme preparation of Cytorecifen.
References
L.A. Blatun, “Local medicamentous treatment of wounds”, Khirurgiia (Mosk), no. 4, pp. 51–60, 2011 (in Russian).
Y.K. Abaev, “Drugs in the treatment of wounds”, Medecinskie Znaniya, no. 6, pp. 2–5, 2010 (in Russian).
N.S. Demina, “Substance for dermatological pharmaceuticals based on collagenase microbial origin "Ultralizine"”, RF Patent 2 340 371, Dec. 10, 2008.
G.N. Rudenskaja et al., “The therapeutic effect of the ointment Moricrol”, Vestnik Moscow. univ-ta., Ser. 2. Himija, vol. 41, no. 6, pp. 415 – 417, 2000 (in Russian).
G.N. Kreytsberg et al., “Ointment for the treatment of infected wounds “ARGOLON”, RF Patent 2 397 752, Jan. 27, 2010.
A.G. Beniashvili et al., “Pharmaceutical composition for topical use having anti-bacterial and nekroliticescoe properties”, RF Patent 2 367 456, Sep. 20, 2009.
B.M. Datsenko, “Studies of polyethylene oxides for their clinical application in a chronological presentation”, Harkivska Hirurgichna shkola, no. 2.1 (33), pp. 21–24, 2009 (in Russian).
M.A. Grygoreva, “Biotechnology immobilized hydrolytic enzyme preparation of Cytoretsifen -M”, Ph.D dissertation, NUFT, Kyiv, Ukraine, 2009 (in Ukrainian).
T.S. Todosiychuk et al., “Physico-chemical aspects of interaction of the enzyme complex Cytoretsifen with carriers of different nature”, Naukovi Visti NTUU KPI, no. 2, pp. 108–113, 2009 (in Ukrainian).
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