Indolequinoxalines Derivatives – Promising Compounds with Antiviral and Interferon Inducing Actions

Тетяна Андріївна Богун, Лілія Григорівна Жолнер, Тетяна Іванівна Бикова, Надія Михайлівна Жолобак, Микола Якович Співак

Abstract


Background. The development of new drugs with antiviral activity and the ability to induce interferon is an urgent task, taking into account the rapid spread of viral infections, development of resistance the virus strains to existing antiviral drugs and the overall decline of the immune response.

Objective. Determine the antiviral activity and interferon inducer actions of indolequinoxalines derivatives in terms of in vitro.

Methods. The work on PST cell cultures in conditions of in vitro antiviral and interferon inducer of the 18 new indolequinoxalines derivatives was studied.

Results. The ability of indolequinoxalines derivatives to inhibit the development of viral cytopathic effect on the model PST-BBC only in therapeutic regimens was shown. In the model of inoculated cell cultures PST is shown that 12 compounds are capable of inducing interferon in low concentrations.

Conclusions. Among the indolequinoxalines derivatives RG-61 compound as a promising for further studies was identified, which has a low toxicity (as compared to a number of compounds derived), has antiviral activity in infected cells and is capable of inducing IFN.


Keywords


Interferon inducers; Antiviral activity; Vesicular stomatitis virus; Interferon-inducing action; Amiksin; Derivatives of indolohinoksalin

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DOI: http://dx.doi.org/10.20535/1810-0546.2016.3.68691

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