Antiviral and Interferon-Inducing Action of Aminoethoxydiphenyls

Олена Віталіївна Шемендюк, Лілія Григорівна Жолнер, Надія Михайлівна Жолобак, Микола Якович Співак


Background. Synthesized compounds 4,4¢-bis(2-R-ethoxy)diphenyl characterized as intercalation into DNA and antiviral activity and ability to induce interferon.

Objective. Determine the antiviral activity and interferon inducer actions of diphenyl derivatives – analogues of Amiksin, in terms of in vitro.

Methods. The work on cell cultures PST and MDBK in conditions in vitro studied antiviral and interferon inducer of the new structural analogues og Amiksin: 4,4¢-bis-(2-dimethylamino-ethoxy)diphenyl, 4,4¢-bis-(2-4-metylpiperydyno-ethoxy)diphenyl and 4,4¢-bis-(2-[2-methyl-2-(4-metylpiperazyn-1-yl)-propil]amino-ethoxy)diphenyl.

Results. Diphenyl derivatives shown the ability to inhibit the development of viral cytopathic effect on the model PST-BBC as in prophylactic and therapeutic regimens in compounds. In the model of inoculated cell cultures PST shown that compounds like Amiksin capable of inducing interferon, their advantage is much less toxicity. With the introduction of experimental animals experimental compounds IFN gene-active substances have been better than Amiksin.

Conclusions The results can be considered as derivatives of diphenyl compounds that are able to provide virus protection cells not only due to the activation of interferon production, but other mechanisms, the study of which is the goal of future research.


Amiksin; Antiviral activity; Vesicular stomatitis virus; Interferon inducing action; Diphenyl derivatives


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