Antiviral and Interferon-Inducing Action of Aminoethoxydiphenyls
DOI:
https://doi.org/10.20535/1810-0546.2015.3.61925Keywords:
Amiksin, Antiviral activity, Vesicular stomatitis virus, Interferon inducing action, Diphenyl derivativesAbstract
Background. Synthesized compounds 4,4¢-bis(2-R-ethoxy)diphenyl characterized as intercalation into DNA and antiviral activity and ability to induce interferon.
Objective. Determine the antiviral activity and interferon inducer actions of diphenyl derivatives – analogues of Amiksin, in terms of in vitro.
Methods. The work on cell cultures PST and MDBK in conditions in vitro studied antiviral and interferon inducer of the new structural analogues og Amiksin: 4,4¢-bis-(2-dimethylamino-ethoxy)diphenyl, 4,4¢-bis-(2-4-metylpiperydyno-ethoxy)diphenyl and 4,4¢-bis-(2-[2-methyl-2-(4-metylpiperazyn-1-yl)-propil]amino-ethoxy)diphenyl.
Results. Diphenyl derivatives shown the ability to inhibit the development of viral cytopathic effect on the model PST-BBC as in prophylactic and therapeutic regimens in compounds. In the model of inoculated cell cultures PST shown that compounds like Amiksin capable of inducing interferon, their advantage is much less toxicity. With the introduction of experimental animals experimental compounds IFN gene-active substances have been better than Amiksin.
Conclusions The results can be considered as derivatives of diphenyl compounds that are able to provide virus protection cells not only due to the activation of interferon production, but other mechanisms, the study of which is the goal of future research.
References
N.Ya. Spivak et al., “Antibacterial efficacy of interferon and its inducers”, Mikrobiologicheskij Zhurnal, vol. 61, no. 1, pp. 32–46, 1999 (in Russian).
D.S. Shay et al., “Interferongene activity of analogues of amiksan and derivatives of biphenyl”, Mikrobiologicheskij Zhurnal, vol. 69, no. 5, pp. 59–64, 2007 (in Ukrainian).
A. Wacker et al., “Distribution of 14C-Tilorone in mice”, Naturwissenschaften, no. 59, p. 520, 1972.
Tiloronum [Online]. Avaliable: https://ru.wikipedia.org/wiki/%D0%A2%D0%B8%D0%BB%D0%BE%D1%80%D0%BE% D0%BD.
S.A. Zanoza et al., “Synthesis and cytotoxicity of aminoetoksydyfenily”, Zhurnal Orhanichnoyi ta Farmatsevtychnoyi Khimiyi, vol. 12, no. 3, pp. 38–44, 2014 (in Ukrainian).
M.O. Shibinskaya et al., “Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6h-indolo[2,3-b]quinoxalines”, Europ. J. Med. Chem., vol. 45, no. 3, pp. 1237–1243, 2010.
F.I. Ershov and O.I. Kiselev, Interferons and their Inducers (from Molecules to Drugs). Moscow, Russia: GOETAR-Media, 2005, 368 p. (in Russian).
A.E. Medvedev et al., “A study of the action of immunosuppressive factors from tumour cells on lymphocytes and macrophages in vitro and on the graft-versus-host reaction in mice”, Biomed. Sci., vol. 1, no. 3, pp. 261–266, 1990.
L.N. Lazarenko et al., HPV Infection and Interferon System. Kyiv, Ukraine: Fitosotsiotsentr, 2008, pp. 237–238 (in Ukrainian).
D.A. Novikov and V.V. Novochadov, Statistical Methods in Biomedical Experiments (Typically). Volgograd, Russia: VSMU, 2005, 84 p. (in Russian).
Downloads
Published
Issue
Section
License
Copyright (c) 2017 NTUU KPI Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under CC BY 4.0 that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work
