Immunomodulating Properties of Probiotics Based on Lactobacteria and Plant Components

Authors

  • Лариса Борисівна Орябінська NTUU KPI, Ukraine
  • Белюр Д. Прасанна National Institute of Technology Karnataka, Surathkal, Mangalore, India, India
  • Людмила Миколаївна Лазаренко D.K Zabolotny Іnstitute of microbiology and virology of the NASU,
  • Олексій Мартем’янович Дуган NTUU KPI, Ukraine

DOI:

https://doi.org/10.20535/1810-0546.2014.3.53503

Keywords:

Probiotic, Lactic acid bacteria, Immune response

Abstract

Purpose of this work was determination of the immunomodulatory effects of base probiotic composition of lactic acid bacteria based on genus Lactobacillus and the complex probiotic with carbyuloza on an experimental model of intact mice. It was found, that injection of carbyuloza in the probiotic composition increased functional activity of phagocytic system – namely, absorbing activity of macrophages. After injection of complex composition to intact mice, there was a tendency to increase the number of CD19+ B-lymphocytes, CD25+ cells in the spleen including activated T- and B-lymphocytes and activated macrophages. In addition, under the influence of net carbyuloza in spleens of mice the number of CD4+ cells (on 9th day ), and CD25+ cells (at the third day and 6th) where up. The received data indicate the potential ability of a base composition of the probiotic and complex preparation with carbyuloza guide to the development of the immune response to cell type which is important in protecting against bacterial and viral pathogens.

Author Biographies

Лариса Борисівна Орябінська, NTUU KPI

Oryabinska Larysa B., candidate of sciences (biology), associate professor, assistant professor

Белюр Д. Прасанна, National Institute of Technology Karnataka, Surathkal, Mangalore, India

Prasanna D. Belur, phD

Людмила Миколаївна Лазаренко, D.K Zabolotny Іnstitute of microbiology and virology of the NASU

Lazarenko Ludmyla M., doctor of biological sciences, senior research fellow

Олексій Мартем’янович Дуган, NTUU KPI

Dugan Alexey M., doctor of biological sciences, full professor, head of department, dean of faculty of biotechnology and bio­engineering

References

Старовойтова С.О. Розробка композиції поліштамового пробіотику на основі бактерій роду Lactobacillus: Дис. канд. біол. наук: 03.00.20. – К., 2008. – 176 с.

Янковський Д.С. Мікробіологічна характеристика системи “організм господаря – мікробіоценози різних екологічних ніш”, як основа створення мультипробіотиків нових поколінь: автореф. дис. … д-ра біол. наук: спец. 03.00.07 “Мікробіологія”. – Х., 2006. – 52 с.

Папіломовірусна інфекція та система інтерферону / Л.М. Лазаренко, М.Я. Співак, О.М. Михайленко, Г.Т. Сухих. – К.: Фітосоціоцентр, 2005. – 288 с.

Лимфоциты: Методы / Пер. с англ.; под ред. Дж. Клауса. – М.: Мир, 1990.– 396 с.

Современные методы диагностики вирусных респираторных инфекций и их терапии с использованием препаратов интерферона и его индукторов / Н.С. Дяченко, Н.Я. Спивак, Л.А. Тарастишин и др. // Метод. рекомендации. – К., 1994. – 18 с.

Влияние препаратов интерферона α/β- и γ-типов на функциональную активность макрофагов при экспериментальной стафилококковой инфекции / Н.Е. Вихоть, Н.Я. Спивак, Л.Н. Черная, Е. Пастер // ЖМЭИ. – 1989. – № 4. – С. 57–60.

N.H. Shah et al., “Carboxymethylcellulose: effect of degree of polymerization and substitution on tablet disintegration and dissolution”, J. Pharm. Sci, no. 70 (6), pp. 28–43, 1981.

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Published

2014-06-27

Issue

No. 3 (2014): Chemical and Biological Sciences and Technologies

Section

Art

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