The Study of 99mTc Production Using Medical Cyclotrons in Ukraine
Background. Tracer production for nuclear medicine.
Objective. The aim of the paper is to consider the possibility of 99mTc tracer production using low-energy medical cyclotrons installed in Ukraine applying enriched 100Мо targets.
Methods. The cross sections of 100Mo(p,2n)99mTc nuclear reactions and reactions, leading to formation of impurities were calculated. The technical aspects of irradiation process were considered. Necessary target thickness and 99mTc tracer yield for the Eclipse RD (Siemens) and PETtrace (GE) cyclotrons were estimated.
Results. Within the framework of proposed concept, 99mTc tracer yield equals 3.7 and 35.5 GBq after 2h of bombardment for Eclipse RD and PETtrace cyclotrons, respectively.Conclusions. The obtained results showed satisfied 99mTс tracer yields and feasibility of further development of this method, which will significantly improve the efficiency of cyclotron installations.
S.M. Qaim et al., “Evaluation of excitation functions of 100Mo(p,d+pn)99Mo and 100Mo(p,2n)99mTc reactions: Estimation of long-lived Tc-impurity and its implication on the specific activity of cyclotron-produced 99mTc”, App. Rad. Isot., vol. 85, pp. 101–113, 2014. doi: 10.1016/j.apradiso.2013.10.004
J. Beaver and H. Hupf, “Production of 99mTc on a medical cyclotron: A feasibility study”, J. Nucl. Med., vol. 12, pp. 739–741, 1971.
T.J. Ruth, “The medical isotope crisis: How we got here and where we are going”, J. Nucl. Med. Technol., vol. 42, pp. 245–248, 2014. doi: 10.2967/jnmt.114.144642
K. Gagnon et al., “Cyclotron production of 99mTc: Experimental measurement of the 100Mo(p,x)99Mo, 99mTc and 99gTc excitation functions from 8 to 18 MeV”, Nucl. Med. Biol., vol. 38, pp. 907–916, 2011. doi: 10.1016/j.nucmedbio.2011.02.010
K. Buckley, “Cyclotron production of Tc-99m”, in Proc. 20th Int. Conf. Cyclotrons 2013, Vancouver, BC, Canada, 2013, pp. 482–486.
F. Bendar et al., “Implementation of multi-curie production of 99mTc by conventional medical cyclotrons”, J. Nucl. Med., vol. 55, no. 6, pp. 1017–1022, 2014. doi: 10.2967/jnumed.113.133413
S. Takacs et al., “Reexamination of cross sections of the 100Mo(p,2n)99mTc reaction”, Nuclear Instruments and Methods in Physics Research, Section B, vol. 347, pp. 26–38, 2015. doi: 10.1016/j.nimb.2015.01.056
P. Schaffer et al., “Direct production of 99mTc via 100Mo(p,2n) on small medical cyclotrons”, Physics Procedia, vol. 66, pp. 383–395, 2015. doi: 10.1016/j.phpro.2015.05.048
B.M. Bondar et al., “F-18 production for PET imaging”, in Proc. of 2nd Int. Workshop “Medical Physics – the Current Status, Problems, the Ways of Development, Innovation Technologies”, Kyiv, Ukraine, 2012, pp. 70–73.
B.M. Bondar et al., “Radiation safety aspects during 11-MeV medical cyclotron operation and maintenance”, J. Kyiv Univ. News. Ser. Radiophysics and Electronics, vol. 1/2 (21/22), pp. 16–18, 2014.
A.J. Koning and D. Rochman, “Modern nuclear data evaluation with the TALYS code system”, Nuclear Data Sheets, vol. 113, no. 12, pp. 2841–2934, 2014.
M. Herman et al., “EMPIRE: nuclear reaction model code system for data evaluation”, Nuclear Data Sheets, vol. 108, pp. 2655–2715, 2007.
W.R. Leo, Techniques for Nuclear and Particle Physics Experiments: A How-To Approach. Berlin, Heidelberg: Springer-Verlag, 1994.
Report on the 1-st Research Coordinating Meeting on “Accelerator Based Alternatives to Non-HEU Production of 99Mo/99mTc”, Vancouver, Canada, April 16–20, 2012, p. 12.
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