The Study of 99mTc Production Using Medical Cyclotrons in Ukraine

Borys M. Bondar, Igor B. Mikhnytsky, Yaroslav V. Kmetyuk


Background. Tracer production for nuclear medicine.

Objective. The aim of the paper is to consider the possibility of 99mTc tracer production using low-energy medical cyclotrons installed in Ukraine applying enriched 100Мо targets.

Methods. The cross sections of 100Mo(p,2n)99mTc nuclear reactions and reactions, leading to formation of impurities were calculated. The technical aspects of irradiation process were considered. Necessary target thickness and 99mTc tracer yield for the Eclipse RD (Siemens) and PETtrace (GE) cyclotrons were estimated.

Results. Within the framework of proposed concept, 99mTc tracer yield equals 3.7 and 35.5 GBq after 2h of bombardment for Eclipse RD and PETtrace cyclotrons, respectively.

Conclusions. The obtained results showed satisfied 99mTс tracer yields and feasibility of further development of this method, which will significantly improve the efficiency of cyclotron installations.


Tracer production; Cyclotrons; Nuclear medicine

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