Heat and Mass Transfer Remote Control in Bioreactors of Technological Lines

Viktorija M. Mel’nick, Sergei V. Fesenko


Background. The main problems that arise when using equipment for cultivation are to ensure the heat and mass transfer processes in devices, presence of turbulent and stagnant zones, high-energy consumption, low heat transfer coefficients when working with viscous fluids.

Objective. The aim of the paper is the experimental determination of the remote control heat transfer advantages in production line bioreactors using ultrasonic beam compared to contact methods.

Methods. An experimental study of the heat and mass transfer process in a bioreactor on the stand with UZP-6-1 immersion unit of the ultrasonic radiator with radiation frequency 42 kHz is carried out.

Results. Sound waves emitted into a liquid form a concentration zone of passable sound energy in the confocal vessel form of a cylindrical surface and force the liquid to move along the inner surface of the glass along the ascending cylindrical spiral, forming a motive flow throughout the volume, causing peripheral layers of liquid and bottom layers to move in a horizontal and vertical planes, without leaving stagnant zones. The closer to the coincidence angle  is the directed ultrasonic beam the greater is the effectiveness of the driving flow.

Conclusions. The use of sound waves allows obtaining a high-quality product in technological lines based on bioreactors with minimal risk for the technological process. Radiation parameters and working volume physic-mechanical properties change allow fully using the properties of resonant manifestations of the sound wave influence on the working liquid with minimal costs.


Bioreactor; Aberration; Caustic zone


Y.I. Sidorov, Processes and Devices of Microbiological and Pharmaceutical Industries. Lviv, Ukraine: Intelect-Zahid, 2008 (in Ukrainian).

Y.I. Sidorov, “Capacitive type laboratory fermenters”, Biotekhnologiya, vol. 5, pp. 33–41, 2012 (in Ukrainian).

Yu.M. Penchuk et al., “Equipment for remote plant cell growing”, Kharchova Promyslovist, no. 13, pp. 39–42, 2012 (in Ukrainian).

V.Y. Kyslikh et al., “Gradientless gas-vortex bioreactors in modern biotechnology”, Intehral, no. 2 (22), pp. 78–79, 2005 (in Russian).

V. Mel’nick and V. Karachun, “The emergence of resonance within acoustic fields of the float gyroscope suspension”, East.-Eur. J. Enterprise Technol., vol. 1, no. 7, pp. 39–44, 2016. doi: 10.15587/1729-4061.2016.59892

K. Durbha and K. Aravamudan, “Quantification of surface area and intrinsic mass transfer coefficient for ultrasound-assisted dissolution process of a sparingly soluble solid dispersed in aqueous solutions”, Ultrasonics Sonochemistry, vol. 19, no. 3, pp. 509–521, 2012. doi: 10.1016/j.ultsonch.2011.09.008

S.V. Pereira et al., “Ultrasound influence on the solubility of solid dispersions prepared for a poorly soluble drug”, Ultrasonics Sonochemistry, vol. 29, pp. 461–469, 2016. doi: 10.1016/j.ultsonch.2015.10.022

V. Mel’nick et al., “Construction of mathematical model of dissolution process of solids under action of ultrasound”, Technology Audit and Production Reserves, no. 1/3 (33), pp. 28–33, 2017. doi: 10.15587/2312-8372.2017.93629

GOST Style Citations

DOI: https://doi.org/10.20535/1810-0546.2017.5.101726


  • There are currently no refbacks.

Copyright (c) 2017 Igor Sikorsky Kyiv Polytechnic Institute

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.