Antiviral and Interferon-Inducing Action of Aminoethoxydiphenyls

Authors

DOI:

https://doi.org/10.20535/1810-0546.2015.3.61925

Keywords:

Amiksin, Antiviral activity, Vesicular stomatitis virus, Interferon inducing action, Diphenyl derivatives

Abstract

Background. Synthesized compounds 4,4¢-bis(2-R-ethoxy)diphenyl characterized as intercalation into DNA and antiviral activity and ability to induce interferon.

Objective. Determine the antiviral activity and interferon inducer actions of diphenyl derivatives – analogues of Amiksin, in terms of in vitro.

Methods. The work on cell cultures PST and MDBK in conditions in vitro studied antiviral and interferon inducer of the new structural analogues og Amiksin: 4,4¢-bis-(2-dimethylamino-ethoxy)diphenyl, 4,4¢-bis-(2-4-metylpiperydyno-ethoxy)diphenyl and 4,4¢-bis-(2-[2-methyl-2-(4-metylpiperazyn-1-yl)-propil]amino-ethoxy)diphenyl.

Results. Diphenyl derivatives shown the ability to inhibit the development of viral cytopathic effect on the model PST-BBC as in prophylactic and therapeutic regimens in compounds. In the model of inoculated cell cultures PST shown that compounds like Amiksin capable of inducing interferon, their advantage is much less toxicity. With the introduction of experimental animals experimental compounds IFN gene-active substances have been better than Amiksin.

Conclusions The results can be considered as derivatives of diphenyl compounds that are able to provide virus protection cells not only due to the activation of interferon production, but other mechanisms, the study of which is the goal of future research.

Author Biographies

Олена Віталіївна Шемендюк, Zabolotny Institute of Microbiology and Virology of NAS of Ukraine

Olena V. Shemendyuk, Senior Laboratory worker at the Department of Problems of Interferon and Immunomodulators

Лілія Григорівна Жолнер, National Technical University of Ukraine «Kyiv Polytechnic Institute»

Lilia G. Zholner, Ph.D., Associate Professor at the Department of Industrial Biotechnology of the Faculty of Biotechnology and Bioengineering

Надія Михайлівна Жолобак, Zabolotny Institute of Microbiology and Virology of NAS of Ukraine

Nadiya M. Zholobak, Ph.D., Senior Research Fellow at the Department of Problems of Interferon and Immunomodulators


Микола Якович Співак, Zabolotny Institute of Microbiology and Virology of NAS of Ukraine

Nicholas Ya. Spivak, doctor of biological sciences, professor, correspondent member of NAS of Ukraine, Head of Department of Problems of Interferon and Immunomodulators

References

N.Ya. Spivak et al., “Antibacterial efficacy of interferon and its inducers”, Mikrobiologicheskij Zhurnal, vol. 61, no. 1, pp. 32–46, 1999 (in Russian).

D.S. Shay et al., “Interferongene activity of analogues of amiksan and derivatives of biphenyl”, Mikrobiologicheskij Zhurnal, vol. 69, no. 5, pp. 59–64, 2007 (in Ukrainian).

A. Wacker et al., “Distribution of 14C-Tilorone in mice”, Naturwissenschaften, no. 59, p. 520, 1972.

Tiloronum [Online]. Avaliable: https://ru.wikipedia.org/wiki/%D0%A2%D0%B8%D0%BB%D0%BE%D1%80%D0%BE% D0%BD.

S.A. Zanoza et al., “Synthesis and cytotoxicity of aminoetoksydyfenily”, Zhurnal Orhanichnoyi ta Farmatsevtychnoyi Khimiyi, vol. 12, no. 3, pp. 38–44, 2014 (in Ukrainian).

M.O. Shibinskaya et al., “Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6h-indolo[2,3-b]quinoxalines”, Europ. J. Med. Chem., vol. 45, no. 3, pp. 1237–1243, 2010.

F.I. Ershov and O.I. Kiselev, Interferons and their Inducers (from Molecules to Drugs). Moscow, Russia: GOETAR-Media, 2005, 368 p. (in Russian).

A.E. Medvedev et al., “A study of the action of immunosuppressive factors from tumour cells on lymphocytes and macrophages in vitro and on the graft-versus-host reaction in mice”, Biomed. Sci., vol. 1, no. 3, pp. 261–266, 1990.

L.N. Lazarenko et al., HPV Infection and Interferon System. Kyiv, Ukraine: Fitosotsiotsentr, 2008, pp. 237–238 (in Ukrainian).

D.A. Novikov and V.V. Novochadov, Statistical Methods in Biomedical Experiments (Typically). Volgograd, Russia: VSMU, 2005, 84 p. (in Russian).

Published

2015-07-03